glp-1 agonist weight loss mechanism GLP1 Receptor Agonists—Effects beyond Obesity and Diabetes Science's 2023 Breakthrough: GLP-1R Agonists

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In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)

10.1038/srep34504 68 FolkmanJ

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