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The study was small, only 34 patients in a relatively homogeneous group mostly white and privately insured

Circulating LH levels were quantified using an ultrasensitive sandwich ELISA, following specific protocols described elsewhere 76

Unlike the naturally occurring GLP-1 hormonewhich breaks down rapidly and has a short duration of actionOzempics semaglutide formulation has been engineered for prolonged activity

Direct modulation of the HPO axis remains a hypothesis that requires further validation through mechanistic trials

Higher app engagement was associated with greater weight loss at 16 weeks

And it worked really well