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GS is constitutively expressed in all cells and has not been studied extensively as GCL [5]
Curr Biol 24:R453R462 Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Tresaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzen HM, Orwar O, Ostman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arner ESJ (2018) Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
By combining distinct peptide mechanisms, researchers can examine how coordinated modulation of pathways such as nitric oxide signaling , cytokine expression , extracellular matrix remodeling , and stem/progenitor cellassociated responses impacts measurable endpoints including healing kinetics , scar architecture , and functional outcomes in tissue physiology
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