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Semaglutide injection and CV impact was evaluated using the SUSTAIN-6 trial (designed as a non-inferiority trials), which primarily showed a reduction in the rate of non-fatal stroke events (RR 0.61

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No DEXA or detailed body composition data published

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It operates across multiple fronts, coordinating what amounts to a full-body regenerative response when administered at therapeutic concentrations

Loren Pickart estimated toxic action starting at approximately 22,500 mg (300-fold above effective doses), though some users report mild blood pressure effects even at normal doses