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In a 2-year, 23 h/day, whole-body inhalation study on rats, 0.48 mg/m 3 caused inhibition of plasma and erythrocyte activity, but brain AChE activity was not inhibited and there were no clinical signs

This might involve longer contact time with the body stick, application to slightly damp skin for enhanced penetration (only for non-sensitive areas like elbows and knees), or combining with occlusive treatments like cotton gloves or socks for overnight penetration enhancement

Safi R, Gardaneh M, Panahi Y, Maghsoudi N, Zaefizadeh M, Gharib E

In addition, PD hyperhomocysteinemia has been linked to dementia, depression, disease progression, cognitive deterioration, and vascular diseases

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