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The development of digital medical record systems 5 and the implementation of the Veterans Health Information System and Technology Architecture 6 enabled large-scale collection of clinical information in the form of electronic health records (EHR)

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When mitochondrial depolarization damage occurs, the mitochondrial membrane potential (MMP) decreases, and PINK1 hydrolysis is inhibited, which stably binds to the damaged mitochondrial outer membrane, recruiting Parkin to translocate from the cytoplasm to the mitochondrial outer membrane, thereby phosphorylating and activating Parkin activity (Uoselis et al., 2023)

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