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It helps prevent moisture loss from a compromised skin barrier and increases the density of skin fibers, enhancing skin elasticity

But it also reported complete weight regain after two years in: It takes a lot of effort to keep that weight off once you stop taking a GLP-1, says Dr

Most patients experience semaglutide side effects within 24 to 48 hours after their first injection or dose increase, with peak symptoms typically occurring between days 3 and 5

2025;21(6):e70389

To reduce GLP-1 side effect risk, start with smaller meals, eat more slowly, and keep very fatty foods moderate while your dose increases