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Safety Profile and Side Effects Safety is the top priority for any treatment affecting the brain

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Engagement of NTS Glu8.2 Calcr/Prlh neurons by cagrilintide in rats but not in mice To identify cellular mediators of cagrilintide action, we used expression of the immediate early gene Fos and its downstream target genes (the Fos regulon) as a transcriptional proxy for neuronal activation

The recommendation surprised many observers

35 Obstructive sleep apnoea In a one-year study of adults with moderate to severe obstructive sleep apnoea and obesity in whom about a half were treated with positive airway pressure at baseline and the remainder were untreated, treatment with tirzepatide 10 or 15 mg once weekly resulted in a clinically meaningful reduction in the apnoeahypopnoea index in both groups compared with placebo

Importantly, these weight loss benefits were sustained with a reported weight loss of 5.7 kg over 52 weeks [66]