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NICE guidance recommends at least 150 minutes of moderate-intensity aerobic activity per week, following a Mediterranean-style diet, reducing refined carbohydrates and added sugars, and limiting alcohol consumption in line with UK Chief Medical Officers' guidance

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High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism

Some people might experience significant weight loss, which may or may not be desirable

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The majority of subjects with elevated serum creatinine also had abnormal values at baseline