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Vzquez-Meza H, Vilchis-Landeros MM, Vzquez-Carrada M, Uribe-Ramrez D, Matuz-Mares D

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In particular, SKN increased nitric oxide production through upregulation of endothelial nitric oxide synthase and proliferator-activated receptor alpha expression, while simultaneously decreasing iNOS, COX-2, and other oxidative markers

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In addition, a very intriguing ROS-related molecular mechanism of tumor suppression by p53 has recently been highlighted