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Anatomy of the endocrine system

doi:10.1056/NEJMoa2312323 Miller-Matero LR, Yeh HH, Ma L, et al

Signs and Symptoms of Menstrual Cramps Throbbing, cramping, or aching in the lower abdomen Pain that radiates to the lower back and thighs In more severe cases, symptoms may also include: Causes and Risk Factors of Menstrual Cramps The cause of menstrual cramps varies depending on the type of menstrual cramps you have

TSGIT: an N- and C-terminal tandem tag system for purification of native and intein-mediated ligation-ready proteins

Seek medical attention if you experience: Severe or persistent nausea and vomiting that prevents you from eating or drinking adequately, as this may lead to dehydration Severe abdominal pain , particularly if it radiates to the back, as this could indicate pancreatitis a rare but serious side effect of GLP-1 receptor agonists [1] [2] Signs of dehydration , such as dark urine, dizziness, dry mouth, or reduced urination Frequent hypoglycaemia (low blood sugar episodes), especially if you are also taking sulphonylureas or insulin Unexplained weight loss that seems excessive or concerning Visual changes or symptoms of diabetic retinopathy worsening, which should be monitored in patients with existing eye complications [1] [2] Allergic reactions , such as rash, itching, swelling, or difficulty breathing Upper right abdominal pain, fever or yellowing of the skin or eyes , which could indicate gallbladder problems Reduced urine output, swelling or confusion , which might suggest acute kidney injury Call 999 immediately if you experience severe chest pain, a severe allergic reaction (anaphylaxis) with breathing difficulties, or severe sudden abdominal pain with vomiting

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