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[12] For most people with dietary insufficiency, oral supplementation is effective, as even in the absence of intrinsic factor, approximately 1% of B12 can be absorbed through passive diffusion

In some cases, this can promote the proliferation of B12-dependent intestinal bacteria, further decreasing the proportion of the vitamin available for absorption

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Although it entered phase 1 trials in consideration as a treatment of ulcerative colitis, it has not been approved by the US Food and Drug Administration (FDA) for medical use, and data on human subjects is lacking

Some researchers have surmised that factors such as social isolation from lockdowns, novisitor policies in longterm care facilities, and increased intensive hospitalizations may raise dementia risk at the population level

Clinical Trial Dosing Data AOD-9604 has been evaluated across multiple administration routes and dosing regimens