Focused on short-term, localized injection studies
Tirzepatide is not a GLP-1 receptor agonist monotherapy but is a major incretin competitor (dual GIP/GLP-1)
Data from animal studies further suggest that the appetite suppressant (anorectic) effects of GLP-1R agonists are also manifested through mesolimbic GLP-1R activation, that in turn alters the rewarding value of food [23,24,25,26,27,28,29]
The discussion explores how ketogenic diets can shift the body from glucose to fat burning, potentially improving brain function and reducing inflammation
Prescribers seeking evidence-based guidance on the neuropsychiatric or affective side effect profile of GLP-1 receptor agonists, including semaglutide, should refer to the published regulatory safety communications from the FDA and EMA, the SUSTAIN and STEP trial data, and peer-reviewed pharmacovigilance literature examining anhedonia, mood changes, and related adverse events in this drug class
His police credentials may have been fake, but Grillo's talent certainly wasn't