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People with sulfa allergies can generally take semaglutide safely, as it does not contain sulfa or sulfonamides

clinical significance likely low Levothyroxine / recheck TSH 6 to 8 weeks after starting or up-titrating any GLP-1 RA Acetaminophen PK / exenatide delayed acetaminophen Tmax by 2.2 hours in a crossover study Metformin / no clinically meaningful interaction

This does not mean the medicine is harming the heart, but it can be confusing or scary