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Arch Neurol 69:836841 Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R (2012) A randomized controlled pilot trial of oral N-acetylcysteine in children with autism
EGb also improved sleep quality in depressed inpatients by increasing sleep efficiency, enhancing non-REM slow-wave sleep, and reducing awakenings, likely via modulation of CRH activity
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finally, in terms of limitations, it highlights the heterogeneity in evidence [e.g., variations in Omega-3 dosing across RCTs (65)] and population-specific biases [e.g., vitamin D studies focusing on IBD patients (169)]