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Modified Ringer solutions

To induce hyperglycemia, STZ (Fujifilm Wako Pure Chemical Industries, Japan) was used based on a previous report 38

It was noted that the AEs were more common with 10 and 15 mg tirzepatide compared to the 5 mg tirzepatide and semaglutide groups [9]

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348 This weakened signaling triggers the activation of JAK2/STAT3 and C/EBP signaling pathways in the AD brain and inhibits downstream Akt signaling molecules, 349 thereby promoting the activation of asparagine endopeptidase (AEP

Only reconstitute what you plan to use within the stability window