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Some people notice slight changes in appetite or "food noise" (those constant thoughts about food), or feel fuller sooner when eating

In the absence of IRE1 activity, the unspliced XBP1 protein (~ 29 kDa) is rapidly degraded (Tirosh et al

this prompted calls to update drug labeling

Medical Context: Obesity is recognized by major medical organizations including the American Medical Association, American College of Cardiology, and The Obesity Society as a chronic disease requiring long-term medical management, similar to hypertension, diabetes, or hyperlipidemia

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