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[5] Serum 25-hydroxyvitamin D, calcium, phosphate, and parathyroid hormone are re-examined at least eight weeks after each injection, and maintenance may shift to oral 1,000-2,000 IU daily once target levels (generally 30-50 ng mL ) are achieved, thereby reducing the risk of cumulative overdose while safeguarding skeletal health

Rapamycin, an inhibitor of mammalian target of rapamycin (mTOR) complex 1, exhibits cardioprotective effects in ferroptotic cells, where mTOR overexpression protects against iron-overload-induced cell death, a process exacerbated by mTOR deficiency (67, 68)

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doi: 10.1021/acs.biochem.6b00124 200 Martins GomesS