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In 2023 the FDA placed it in Category 2 of its interim compounding list, meaning the agency flagged significant safety risks and did not clear it for pharmacy compounding

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Reported applications include radioligand and fluorescent binding assays at CTR and AMY1 to AMY3, cAMP accumulation and other Gs-pathway readouts, receptor internalisation and regulation studies, and structural biology: Cao and colleagues (Nat Commun, 2025) reported cryo-EM structures of cagrilintide bound to calcitonin and amylin receptors with associated PDB depositions

Persistent large bubbles may indicate a compromised cartridge seal

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