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Cells were lysed in 100 L ice cold 8 M Urea/50 mM Tris HCl lysis buffer (Fisher Scientific) with 1:100 of Halt Cocktail Inhibitor, EDTA-free (100X) (Thermo Scientific)

Notch intracellular domain regulates glioblastoma proliferation through the Notch1 signaling pathway

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Chiricozzi A, Chimenti S

Phase 2 data published in the New England Journal of Medicine showed mean body weight reductions of up to 24.2% at the highest dose tested over 48 weeks [8]

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