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These agents include thiazolidinediones (PPAR- agonists), dipeptidyl peptidase-4 (DPP-4) inhibitors, sulfonylureas, sodium-glucose co-transporter 2 (SGLT2) inhibitors, -glucosidase inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists

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When GLP-1 receptors activate in the brain, they trigger satiety signals that decrease hunger and food-seeking behavior

Notably, even after stopping the drug, some weight loss benefit persisted long-term, albeit much weaker than with continued treatment

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