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10.1016/j.neuropharm.2014.05.030 Neuropharmacology

While these are research rather than approved treatment contexts, they reflect the mechanisms particular relevance to cardiac tissue health

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Because of the anatomical arrangement of the liver and the pancreas, when insulin is released from the -cells of the pancreas into the portal circulation nearly 50% is captured (also referred to as extracted) by hepatocytes

These appear to be less important, however, as restoring GLP-1R in the pancreas in a receptor KO mouse restored glucose tolerance (61)

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