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The net effect in research models involves substantial changes in energy balance, lipid mobilization, and glucose homeostasis providing a uniquely comprehensive tool for studying multi-receptor metabolic regulation

Obesity, inflammation, and atherosclerosis

Clinical implication Considering the potential for gastric food retention and aspiration risks associated with surgical or endoscopic interventions, the American Society of Anesthesiologists recommends the discontinuation of short-acting GLP-1 RAs one day and long-acting formulations at least 1 week before surgical procedures [27]

This includes any possible side effects not listed in the patient information leaflet

These findings further underscore the notion that GLP-1R plays pivotal roles in both diseases

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