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10.1038/jcbfm.2015.44 J

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Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog

The absence of leg cramps from official labeling does not definitively rule out a connection, as post-marketing experience sometimes reveals adverse effects not detected in pre-approval trials due to sample size limitations, duration of follow-up, or patient population differences

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