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Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation
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On the other hand, exclusion criteria included (1) review articles with poor experimental data, (2) research studies without clear methodologies, (3) research articles unrelated to pharmaceutical prospect of antioxidants and (4) publications without scope of our research work, (5) non-peer-reviewed studies, (6) literature older than 25 years, as well as (6) unpublished work
Causes of Falsely Elevated Serum Homocysteine and Methylmalonic Acid Levels Pernicious anemia should be suspected in patients without an obvious cause of malabsorption or who have a coexisting autoimmune disorder, such as vitiligo or thyroiditis
doi: 10.1371/journal.pone.0114881 134
