In addition to these findings on atherosclerotic plaque formation, GLP-1R agonists prevented the increase in plasminogen activator inhibitor type-1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1) gene expression in response to TNF- or hyperglycemia in HUVEC through PKA pathway [24],[70]
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These drugs that are FDA-approved for the treatment of diabetes have emerged as a promising new tool in the fight against obesity
doi: 10.1111/cas.12096 64 YangCWeiCWangSShiDZhangCLinXet al
Many of these medications can be used on a short- or long-term basis in combination with lifestyle changes
The news is largely positive
