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On the other hand, an elevated concentration of homocysteine, and its metabolites such as homocysteine thiolactone and N-homocysteinyllysine result in health problems and has been indicated as an independent risk factor for cardiovascular disease and accelerated atherosclerosis

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But this same mechanism creates a downstream nutritional problem

Studies have shown that smoking cessation results in a decrease in pigmentation, with prevalence similar to that of nonsmokers, seen in patients who have quit the habit for at least 3 years

Plus, to learn more about how to check your vitamin B12 status, see: Vitamin B12 Deficiency Test

However, it is safe to use in combination with carbidopa-levodopa formulations