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Further surgical complications such as fixation failure, sub-optimal tunnel placement, and post-surgical issues like wound re-sutures, patella dislocation, and infection led to the exclusion of some rats from statistical analyses for gait and mechanical test data

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The dose escalation schedule followed a gradual increase pattern designed to minimize gastrointestinal side effects while allowing researchers to identify optimal therapeutic ranges

DSIP is studied in sleep architecture research, stress and ACTH-modulating pathway models, antioxidant pathway investigations, and opioid receptor interaction studies