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Adherence matters more than perfection, and a schedule you actually follow will always beat a more "optimal" schedule you skip

In some embodiments, the formulations or compositions described herein have a pH and osmolarity as described herein, and have a concentration of active pharmaceutical ingredient between about 1 M and about 10 M, between about 1 mM and about 100 mM, between about 0.1 mM and about 100 mM, between about 0.1 mM and about 100 nM

PMID: 17513701

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Is one better than the other

The patient may notice a lump of filler which can move (migrate) over time