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The weight loss was gradual, with results beginning at around week four and continuing to increase until the end of the trial at week 24

k , Glucose tolerance test on day 4

Neuron 110 , 11931210 e1113 (2022)

AASLD, ACG, AGA, ASGE, NASPGHAN

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Additionally, conflicting findings suggest that prolonged metformin treatment may exacerbate AD pathology in genetically susceptible models, increasing -amyloid accumulation, tau phosphorylation, and synaptic dysfunction 92