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Because it degrades in blood in a pathway involving amino-peptidases, it may not be suitable for people who take medications that inhibit or are metabolized by peptidases (e.g., captopril, a treatment for hypertension).4 Also, based on what we know about other therapeutic peptides, we would say DSIP is contraindicated for women who are pregnant or breastfeeding as well as people with a personal history of cancer

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In contrast, the tumor suppressor p53 enhances mitochondrial metabolism and OXPHOS by promoting the assembly of cytochrome oxidase (COX) and glycolytic enzymes

NAD+ and glutathione naturally decline with age , contributing to cellular dysfunction, oxidative stress, and increased risk of chronic diseases like Alzheimer's, Parkinson's, and metabolic disorders