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Among them, opioid-induced constipation and nausea are challenging symptoms: they often persist because tolerance does not develop, especially the former

10.1016/j.jpainsymman.2015.12.340 [DOI] [PubMed] [Google Scholar] 4.Ruggiero E, Tizianel I, Caccese M, Lombardi G, Pambuku A, Zagonel V, et al