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Phase 2 clinical trials involved 338 adults with obesity (BMI 30 or more) and overweight (BMI of 2729.99) with one or more weight-related conditions such as high blood pressure, high cholesterol levels, heart disease, and type 2 diabetes

There's now an FDA-approved oral semaglutide option that doesn't require needles, is available by prescription, and has clinical trial data behind it

The vasomodulatory effects of GLP-1RAs also extend to glaucoma models, although the observed outcomes differ