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2020 doi: 10.1016/j.arr.2019.100982

Unfortunately, theres much in todays world that promotes excess free radicals, such as: Pollution High blood sugar levels Alcohol Smoking Infections Exposure to sunlight (radiation) If you combine these outside promoters of free radicals with the fact that many people fall short on antioxidants, you can see why oxidative stress is so common

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APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimers mice via cyclophilin a independently of amyloid-beta