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An increased incidence of micronuclei was observed after one intraperitoneal dose of 100 mg/kg body weight in mice (Lyarskii et al., 1983) and after 4 h of vapour exposure of rats to a concentration of 90 mg/m 3 (Embree & Hine, 1975)

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Unlike outer-sphere electron transfer, the reaction between transition metals and H 2 O 2 occurs via an inner-sphere mechanism, forming a complex before electron transfer (Goldstein et al

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Figure 3 Moreover, increased systematic translocation of intestinal metabolites, bacterial particulates, or even microbiota through the damaged intestinal tract (the leaky gut) heightens systemic inflammatory reactions such as Th17/Treg disorder, interleukin-6, IL-1, and tumor necrosis factors alpha that are being implicated in the etiology of depression