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They have a role in antioxidant defense, but on the other hand, Grxs are able to bind and deliver iron-sulfur clusters, also involved in the deglutathionylation process and in the regeneration of multiple enzymes, such as peroxiredoxins and methionine sulfoxide reductases (Rouhier et al

it crosses the blood-CSF barrier

This qualitative difference suggests the glucagon component contributes something beyond simple appetite suppression, potentially shifting fundamental metabolic set points

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