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This in turn leads to acute reactions such as redness, swelling, and temperature increase

Given the benign mechanism of action and the excellent safety profile observed in trials, serious long-term risks seem unlikely

p53-regulated ferroptotic pathways The tumor suppressor protein p53 (TP53), a powerful multifunctional gene, is activated by many types of stresses, such as DNA damage, nutrition deprivation, hypoxia, or oncogene activation [117]

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