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47 In the endothelial barrier injury associated with ARDS, several signaling pathways have been identified as key regulators, including METTL3-mediated N6-methyladenosine modification of tripartite motif-containing (Trim)59 mRNA, 80 NOX4 activation of CaMKII/ERK1/2/MLCK and Akt-FoxO1/3a signaling pathways, 81 as well as CREB-mediated transcription of VE-cadherin

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