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Both are biologically plausible, and both have limited supportive human evidence

The A1298C variant causes less of a change to the way the enzyme works, with two copies of the variant decreasing enzyme function by around 20%

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Oxidative Stress and Longevity Glutathione depletion correlates with aging and chronic disease

A similar dose-dependent effect on nausea and abdominal discomfort has been found following exogenous administration of PYY 336 in humans (49)