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Achieving the transcriptomic remodeling seen in the mice requires a copper load that is physiologically toxic to humans

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doi: 10.1038/nature07383 136 CadwellKLiuJYBrownSLMiyoshiHLohJLennerzJKet al

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Support the short cut pathway to help restore the methylation pathways without producing too many detoxification symptoms Regulate lithium levels Since lithium is involved in B12 transport, lithium balance is important to the methylation cycle