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Since the great majority of circulating IGF-I is normally sequestered in IGFBP complexes, an analogue that escapes that buffering behaves very differently in any system containing binding proteins, and that is the reason the IGF 1 LR3 variant exists as a reagent at all

By isolating the somatotropic axis, researchers can accurately map receptor kinetics and intracellular calcium mobilization

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[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Gu W.J., Wu Z.J., Wang P.F., Aung L.H.H., Yin R.X