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Additionally, we employed in silico methods to predict the conformational space of the linker and warhead in the reversibly bound state for nucleotide-based compounds to explore the molecular basis for the compounds reactivities and to guide future linker design

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Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4