It is important to remember that GLP-1 RAs are only one piece of the puzzle and should always be recommended in conjunction with diet, exercise and lifestyle modifications
A synthesis of preclinical and population-level evidence now indicates that these agents may influence the development and progression of several OACs, particularly hepatocellular carcinoma (HCC), pancreatic cancer, and colorectal cancer (CRC)
J Clin Pharmacol (2015) 55:1528
Compared with traditional GLP-1 receptor agonists such as Semaglutide and Tirzepatide , Retatrutide performs better in weight management and insulin sensitivity
The vial presentation of Zepbound provides flexibility for healthcare providers and patients
Best for: Patients who want dual-receptor metabolic support, those who have plateaued on semaglutide alone, or those whose provider recommends GIP activation based on their metabolic profile