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These effects arise from both direct microbehost interactions. Dysbiosis markedly diminishes the physiological tolerance of intestinal tissues to ferroptosis, thereby compromising the intestinal barrier function and exacerbating colitis ( 5.1 Ferroptosis regulation based on microbiota-host interaction Iron competition in the gut is a core ecological force that links microbial fitness to host ferroptosis susceptibility

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As estrogen levels fall, muscle and liver cells respond less efficiently to insulin

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