Proper handling is essential, as emphasized in storage guidelines for GLP-1 receptor agonists
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Available as: Last cited 6 Sept 2023 Purnell JQ (2000) Definitions, Classification, and Epidemiology of Obesity
We dont really know yet whether what were seeing on Reddit reflects the experience of GLP-1 users globally, or whether its particular to the kind of person who posts on Reddit in the United States, Ungar says

Data availability Details of the search strategy and list of identified articles can be found at Abbreviations BGM: Blood glucose monitoring CGM: Continuous glucose monitoring CSII: Continuous subcutaneous insulin infusion CVOT: Cardiovascular outcomes trial DKA: Diabetic ketoacidosis DPP-4i: Dipeptidyl peptidase-4 inhibitors DSMES: Diabetes self-management education and support ETD: Estimated treatment difference GIP: Glucose-dependent insulinotropic polypeptide GLP-1 RA: Glucagon-like peptide-1 receptor agonist(s) HF: Heart failure HHF: Hospitalisation for heart failure MACE: Major adverse cardiovascular events MNT: Medical nutrition therapy NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis SGLT1i: Sodiumglucose cotransporter-1 inhibitor SGLT2i: Sodiumglucose cotransporter-2 inhibitor(s) TZD: Thiazolidinedione UACR: Urinary albumin/creatinine ratio References Rodriguez-Gutierrez R, Gionfriddo MR, Ospina NS et al (2016) Shared decision making in endocrinology: present and future directions

Early data from the TRIUMPH trials is undeniably compelling, showing unprecedented weight loss of up to 28.7% at 68 weeks significantly outpacing tirzepatide in early comparisons (see our Retatrutide vs Tirzepatide comparison guide)