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Both short- and long-acting GLP-1RAs such as exenatide, lixisenatide and liraglutide were shown to effectively cross the bloodbrain barrier (BBB) [39,40,41]

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Is there actually any human evidence that this works

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Rubbing can push the peptide out of the subcutaneous layer and increase bruising

Future research should include long-term trials that directly compare equivalent doses of tirzepatide and semaglutide, evaluate the durability of weight maintenance, capture quality-of-life and cardiometabolic outcomes, and explore subgroup responses