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38,39,40,41 Simultaneously, this metabolic alteration benefits T eff cells by reducing their reliance on oxygen for energy production, which enables them to maintain cytokine production and cytolytic activity even when they migrate into microenvironments within solid tumors that have low oxygen levels

Several clustered genes identified by the WGCNA analysis are under the control of Nrf2

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and glutathione synthetase (GS), which adds glycine to complete the tripeptide

352 Elacestrant has emerged as the first FDA-approved oral estrogen receptor antagonist for ESR1 -mutant patients, owing to substantial improvements in progression-free survival (PFS) observed during the EMERALD phase 3 trial in the ESR1 -mutant population