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Biological Activity Cagrilintide and semaglutide, when co-administered, produce synergistic reductions in bodyweight (up to ~1517% over 2032 weeks in clinical trials) and significant improvements in glycemic parameters, including HbA1c and fasting glucose

The cerebellar cortex appeared to be the most affected, and the cerebral cortex was the least affected

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Bulk RNA-Seq has been implemented to analyse single cell RNA (scRNA-Seq), to limit bias given by inter-cellular variability