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Separate vials require two injections (or staggered injections) and add reconstitution overhead, but they let you titrate or hold one compound independently

Asian Pac J Trop Biomed

MS-CU (compound 37, Figure 26) showed stronger binding affinity for all tested proteins (MMP-9, MPO, COX-2, and TNF-) compared to mesalamine alone

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doi:10.1016/S0899-9007(02)00916-4